colIprotect® membrane is a native collagen membrane made of porcine dermis. Its multistep cleaning process ensures the removal of all antigenic and non-collagenous
components,at the same time preserving its natural collagen structure.
The unique processing as well as the open—porous, natural collagen structure of collprotect® membrane are the basis for its safe application in dental bone and tissue regeneration. Owing to its natural hemostatic function, the membrane enables early wound stabilization, thus supporting the natural wound healing. The rough surface of
colIprotect® membrane facilitates a fast integration into the surrounding soft tissue.
– Preserved native collagen structure
– Natural Wound healing and blood clot support
– Easy application and handling in dry or wet status
– Rough and porous structure for cell guidance
Histology six weeks after implantation of collprotect® membrane in a rat model:
Blood vesssels have penetrated the porous structure;collagen fibers are visible, and resorption proceeds without any inflammatory tissue response
NATIVE COLLAGEN MEMBRANE
collprotect® membrane is a native collagen membrane made of porcine dermis, which is intended for dental bone and soft tissue regeneration. The natural, hemostatic effect of collagen enables early wound stabilization and supports the natural healing. Moreover, the collprotect® membrane displays a good surface adaptation and tissue integration and is ideal for most indications where an intermediate stability and easy handling are required.
DENSE AND OPEN POROUS COLLAGEN STRUCTURE
The validated and controlled manufacturing process removes all cells and non-collagenous components, while the natural collagen structure of the tissue of origin is being preserved. collprotect® is a uniform membrane with a thickness of about 0.4 mm. Its three-dimensional structure with open pores facilitates the fast ingrowth of blood vessels and accelerates integration into the surrounding tissue . The general compactness, however, prevents cells from fast migration into the defect area .
The certified manufacturing process of the collprotect® membrane ensures the removal of cells, non-collagenous proteins and potential immunogenic components including bacteria and viruses. Therefore, this membrane is a safe medical device that is regulated according to the EC guidelines with a standardized manufacturing process based on international standards (EN ISO13485).
NATIVE 3-D COLLAGEN STRUCTURE
collprotect® membrane is a native collagen membrane derived from porcine skin (dermis). The dermis is a deeper part of the cutaneous layer and a strong and flexible tissue based on collagen type I and III. The natural structure and biomechanical properties of the dermis are preserved during the manufacturing process. collprotect® membrane presents a dense but porous collagen structure that prevents soft tissue ingrowth, while promoting early revascularization .
The structural unity of the membrane therefore allows placement of both sides to face the defect without affecting its barrier function.
collprotect® membrane exhibits areas of a fibrillary structure within its dense collagen fiber network. These pores originate from the hair follicles of the porcine skin and become recognizable once the hairs have been removed. These pores facilitate the early ingrowth of blood vessels into the defect area through the membrane .
The collprotect® membrane can be applied dry or after rehydration in sterile saline solution or patients own blood. Under dry conditions, the relative stiffness of the membrane allows an upright positioning into the defect or the socket, while filling it with a bone grafting material. After rehydration, the membrane becomes flexible, can easily be placed over the augmentation site, and adapts very well to the surface contours. Although collprotect® membrane supports suturing or pinning, in most cases a fixation is not required due to excellent adhesion- and adaptation properties.
AVOIDANCE OF EXPOSURE
A complete coverage of the defect is recommended at any time, since fast bacterial resorption significantly reduces the barrier and therefore the regenerative function of the collagen membrane. In unstable soft tissue situations, if a wound dehiscence is to be expected, or if the soft tissue does not allow primary closure, a Jason® fleece may be used to cover and protect the collprotect® membrane as well as the healing area.